Daniel H Geschwind Selected Research

Huntington Disease (Huntington's Disease)

7/2012	Network organization of the huntingtin proteomic interactome in mammalian brain.
5/2011	Mithramycin is a gene-selective Sp1 inhibitor that identifies a biological intersection between cancer and neurodegeneration.
3/2011	In vivo cell-autonomous transcriptional abnormalities revealed in mice expressing mutant huntingtin in striatal but not cortical neurons.
9/2010	Inhibition of transglutaminase 2 mitigates transcriptional dysregulation in models of Huntington disease.
10/2008	The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice.

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Daniel H Geschwind Research Topics

Disease

25	Alzheimer Disease (Alzheimer's Disease) 03/2024 - 05/2002
25	Autistic Disorder (Autism) 01/2023 - 01/2006
16	Autism Spectrum Disorder 03/2023 - 01/2008
14	Frontotemporal Dementia (Semantic Dementia) 01/2023 - 05/2002
12	Neurodegenerative Diseases (Neurodegenerative Disease) 03/2024 - 05/2002
11	Dementia (Dementias) 09/2023 - 01/2006
8	Inflammation (Inflammations) 03/2024 - 03/2008
7	Neoplasms (Cancer) 01/2024 - 12/2003
7	Schizophrenia (Dementia Praecox) 01/2023 - 01/2014
6	Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome) 12/2023 - 05/2002
6	Epilepsy (Aura) 01/2023 - 06/2008
6	Tauopathies 01/2023 - 09/2006
5	Parkinson Disease (Parkinson's Disease) 03/2024 - 01/2010
5	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 10/2023 - 09/2008
5	Friedreich Ataxia (Friedreich's Ataxia) 12/2017 - 05/2006
5	Huntington Disease (Huntington's Disease) 07/2012 - 10/2008
4	Intellectual Disability (Idiocy) 01/2023 - 06/2008
3	Pain (Aches) 01/2023 - 08/2003
3	Stroke (Strokes) 01/2023 - 12/2008
3	Neurodevelopmental Disorders 12/2022 - 11/2010
3	Timothy syndrome 01/2022 - 11/2011
3	Glioblastoma (Glioblastoma Multiforme) 01/2022 - 01/2006
3	Primary Progressive Aphasia 01/2019 - 09/2013
3	Fragile X Syndrome (Martin Bell Syndrome) 12/2015 - 07/2008
3	Cognitive Dysfunction 03/2011 - 01/2006
2	Tuberous Sclerosis (Bourneville's Disease) 01/2023 - 01/2017
2	Spinal Cord Injuries (Spinal Cord Injury) 01/2023 - 12/2008
2	Wallerian Degeneration 12/2022 - 12/2020
2	Peripheral Nerve Injuries 10/2022 - 10/2020
2	Bipolar Disorder (Manic Depressive Psychosis) 01/2021 - 12/2018
2	Psychotic Disorders (Schizoaffective Disorder) 01/2021 - 08/2004
2	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2021 - 09/2008
2	Corticobasal Degeneration 01/2019 - 08/2012
2	Autoimmune Diseases (Autoimmune Disease) 12/2016 - 09/2013
2	Hemochromatosis (Bronze Diabetes) 01/2010 - 12/2008
2	Language Disorders (Language Disorder) 11/2008 - 12/2007
1	Synucleinopathies 03/2024
1	Glioma (Gliomas) 01/2024
1	Macular Degeneration (Age-Related Maculopathy) 12/2023
1	Multiple Sclerosis 09/2023
1	Demyelinating Diseases (Demyelinating Disease) 09/2023
1	Ketosis 01/2023
1	Paroxysmal Extreme Pain Disorder 01/2023
1	Erythromelalgia (Erythermalgia) 01/2023
1	Constipation 01/2023
1	Small Fiber Neuropathy 01/2023
1	Developmental Disabilities (Developmental Disability) 01/2023
1	Disease Susceptibility (Diathesis) 11/2022
1	Excoriation Disorder 01/2022

Drug/Important Bio-Agent (IBA)

23	Proteins (Proteins, Gene)FDA Link 03/2024 - 01/2008
11	RNA (Ribonucleic Acid)IBA 01/2024 - 01/2017
10	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 10/2023 - 05/2002
7	ProgranulinsIBA 01/2019 - 07/2008
6	Apolipoproteins E (ApoE)IBA 12/2023 - 01/2006
5	Biomarkers (Surrogate Marker)IBA 10/2023 - 11/2011
5	Transcription Factors (Transcription Factor)IBA 10/2020 - 12/2007
5	Messenger RNA (mRNA)IBA 01/2020 - 07/2007
5	FrataxinIBA 12/2017 - 05/2006
4	Dopamine (Intropin)FDA LinkGeneric 01/2023 - 03/2011
4	Flavin-Adenine Dinucleotide (FAD)IBA 12/2013 - 01/2011
4	ApolipoproteinsIBA 04/2011 - 01/2006
3	alpha-SynucleinIBA 03/2024 - 01/2023
3	L-Type Calcium Channels (Dihydropyridine Receptor)IBA 01/2022 - 11/2011
3	ChromatinIBA 01/2021 - 10/2016
3	DNA-Binding Proteins (DNA Binding Protein)IBA 01/2019 - 09/2008
3	RNA-Binding Proteins (RNA-Binding Protein)IBA 01/2016 - 10/2012
3	Phosphotransferases (Kinase)IBA 01/2009 - 12/2003
2	IntegrinsIBA 03/2024 - 01/2023
2	Amyloid beta-PeptidesIBA 03/2024 - 01/2023
2	tau Proteins (tau Protein)IBA 12/2023 - 10/2019
2	Protein Isoforms (Isoforms)IBA 01/2023 - 12/2018
2	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2023 - 01/2011
2	trans-sodium crocetinate (crocetin)IBA 01/2023 - 01/2017
2	AntibodiesIBA 01/2023 - 10/2019
2	SynucleinsIBA 01/2023 - 09/2015
2	GranulinsIBA 09/2022 - 10/2011
2	Oxytocin (Pitocin)FDA LinkGeneric 10/2021 - 01/2015
2	InterferonsIBA 09/2021 - 10/2015
2	P-2 (P 2)IBA 07/2020 - 05/2014
2	LipidsIBA 09/2019 - 01/2019
2	Long Noncoding RNAIBA 01/2018 - 12/2016
2	Histones (Histone)IBA 11/2016 - 04/2008
2	MicroRNAs (MicroRNA)IBA 11/2016 - 07/2008
2	RNA Splicing FactorsIBA 10/2012 - 05/2011
2	IronIBA 01/2010 - 12/2008
2	Acute-Phase Proteins (Acute-Phase Protein)IBA 05/2009 - 03/2008
2	Histone Deacetylase InhibitorsIBA 10/2008 - 04/2008
1	Complement Receptors (Complement Receptor)IBA 03/2024
1	Complement System Proteins (Complement)IBA 03/2024
1	Presenilin-2IBA 03/2024
1	Voltage-Gated Sodium ChannelsIBA 01/2023
1	Deoxyglucose (2 Deoxy D glucose)IBA 01/2023
1	SodiumIBA 01/2023
1	Histone Acetyltransferases (Histone Acetyltransferase)IBA 10/2022
1	Polysaccharides (Glycans)IBA 10/2022
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 01/2022
1	Macrophage Colony-Stimulating FactorIBA 01/2022
1	Ascorbic Acid (Vitamin C)FDA LinkGeneric 01/2022

Therapy/Procedure

11	Therapeutics 01/2024 - 05/2012
2	Precision Medicine 12/2022 - 11/2015